Preheat the oven to 350 degrees F (175 degrees C).
Heat a large skillet over medium-high heat. Cook and stir beef with garlic and onion powder until browned and crumbly, 5 to 7 minutes. Drain and discard grease.
Spread beef onto the bottom of a 9×13-inch casserole pan. Stir in bacon pieces.
Whisk eggs, heavy cream, salt, and pepper in a medium bowl until well combined. Stir in 8 ounces Cheddar cheese.
Pour egg mixture over the beef and bacon. Top with the remaining 4 ounces cheese.
Bake in the preheated oven until golden brown on top, 30 to 35 minutes.
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